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Nathan appears in the Top 100

Innovators & Entrepreneurs magazine

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Dr. Nathan S. Bryan

“The most gratifying part of our work is knowing that we helped to change a life.”

There are those who pursue science in the name of science. Then there are those for whom science is a calling. For Dr. Nathan S. Bryan, it was a Divine invitation that he could not deny—and one that set him on a decades-long journey. This is the remarkable story of how one man’s sacrifice, devotion, persistence, and defiance led to revolutionary discoveries that are changing the lives of millions.

Dr. Bryan is a trailblazer in the field of nitric oxide-based product technologies with dozens of patents to his name and a successful entrepreneur with several thriving companies that together have delivered nearly a billion dollars’ worth of products to consumers and the medical community. From Bryan Nitriceutical’s nitric oxide-based nutritional products and dietary supplements to Pneuma Nitric Oxide’s skin care and beauty lines to Nitric Oxide Innovations’s drug development program for COVID-19, cardiovascular disease, Alzheimer’s, diabetic and pressure ulcers and other life-threatening and debilitating health conditions, there is almost no category that Dr. Bryan has not touched. And he’s not done yet. “My mission and passion are to continue to advance the science of nitric oxide and innovate new nitric oxide product technology in every major market segment around the world,” he shares.

The (rocky) Road Less Traveled, For the Betterment of All.

“I could never have imagined or planned this journey. I have been blessed beyond measure.” ~ Dr. Bryan

Today, Dr. Bryan leads a trio of companies.  He’s an international leader in molecular medicine and nitric oxide biochemistry, and a former assistant professor of molecular medicine who’s authored hundreds of research papers and books.  But he’s much more than that. He is an inspiring force whose humility belies his extraordinary accomplishments, and whose determination to bring his life-changing nitric oxide products to the masses compelled him to buck the system and tread into the commercial territory traditionally discouraged and sometimes forbidden by academia. And it was anything but easy. Riddled with setbacks, disappointments, betrayal, and sleepless nights, Dr. Bryan refused to give up. “It was only my strong faith in God and support from my family and friends that I endured,” he recalls. “I always knew that the science of nitric oxide could change the world. I was fortunate and blessed enough to figure out how to deliver it safely and effectively to humans.” For the millions of grateful consumers who have benefitted for over a decade from his products—including hundreds of professional, NCAA, and U.S. Olympic team athletes—they undoubtedly feel just as fortunate. 

Pneuma Nitric Oxide, Bryan Nitriceuticals, Nitric Oxide Innovations: Delivering Groundbreaking Products to the Masses

“Simply put, nitric oxide increases blood flow and regulates oxygen and nutrient delivery to every cell in the body. Loss of nitric oxide contributes to diseases of aging.” ~ Dr. Bryan

Pneuma Nitric Oxide is transforming the skin care and beauty industry with their nitric oxide topical products that reduce wrinkles and fine lines, and improve complexion, clarity, and skin texture. Nitric oxide is a natural anti-aging molecule that decreases over time, and by age 40, the body has only about 50% of the production compared to teens and early twenties.  Used by many doctors and medical spas, Pneuma’s N1O1 serum, cleansers, and moisturizers replenish this “beauty molecule” to restore a youthful appearance. Unlike other skin care products that hide or mask blemishes and wrinkles, N1O1 serum gets to the root cause of aging skin.

Bryan Nitriceuticals is a nitric oxide-focused nutrition and dietary supplement company that provides dietary nutritional products and supplements. Their NO2U lozenge is an orally disintegrating tablet that generates nitric oxide gas as it is dissolving.  This lozenge helps support nitric oxide repletion and production to enhance oxygen and nutrient delivery, supporting cardiovascular health, blood pressure, and cognitive and memory function.  If your body cannot make nitric oxide, our technology does it for you.  Their NO Beetz product is an innovative natural energy product that provides the nitric oxide power of fermented beets but without the beet taste, beet color or oxalates.  It also provides electrolytes for hydration and mitochondrial ATP for energy support.  This product is a game-changer in the energy category and should replace all the unhealthy and unsafe energy drinks.

Nitric Oxide Innovations is a clinical-stage biotechnology company focused on developing nitric oxide drugs through the FDA. Their lead drug, Noviricid (Nitrivir©), is currently in phase 3 clinical trials for COVID, and they have drug programs around Alzheimer’s disease, ischemic heart disease, ischemic, non-obstructive coronary artery disease (INOCA) and a topical nitric oxide drug for diabetic and pressure ulcers.  Many other drug indications are in development.

A New Era Begins

“My guiding principle in research is to see what everyone has seen but to think what no one else has thought.” ~ Dr. Bryan


As Dr. Bryan continues to blaze a path with cutting-edge nitric oxide drugs and products, he now has his eye on a bigger mission. “I can proudly say that I’ve thought outside the box, and this has led to many discoveries,” he says. “Now, I’m focused on educating the world on the importance of nitric oxide.”


As part of this special four-page series, we sat down with Dr. Bryan, to hear more about his journey, the science behind nitric oxide, and the overarching vision that guides him: “I want to change the world and leave a lasting legacy on humanity.”

A Conversation with Dr. Nathan S. Bryan


How did your interest in science and medicine blossom into a passion for the study of nitric oxide?

I’ve always been interested in those fields, but I fell in love with the feeling of discovery when I was involved in undergraduate research while pursuing my degree in biochemistry at the University of Texas. While in the PhD program in molecular and cellular physiology at LSU School of Medicine, I was introduced to nitric oxide—and this is where my path became clear. A Nobel Prize had just been awarded for the discovery of how this molecule worked in the body. From that point on, I’ve devoted my entire life’s work to the study of nitric oxide and the development of products that can improve people’s lives—delivering many of them directly into the hands of the consumers, without a prescription. In fact, that was our primary reason for launching Bryan Nitriceuticals, so that people could benefit right now from our nitric oxide-based supplements until our FDA drugs become approved.

Your journey to bring these products to the masses was not without its challenges. Will you share some of the obstacles that you encountered along the way?

I could have never imagined that my life’s journey and hardships would become what my life is today. It was really a divine power that steered me and gave me the courage to continue. My thoughts and ideas were challenged, ridiculed and questioned by my academic colleagues early on. However, I was constantly reminded of the quote by German philosopher Arthur Schopenhauer: “All truth passes through three stages. First, it is ridiculed. Second, it is violently opposed. Third, it is accepted as being self-evident.” My ideas and discoveries turned out to be fundamental truths corroborated by science and clinical translation. Today, nitric oxide as a science and as a viable therapeutic candidate for many, if not most, human diseases is evident. My mission and passion are to continue to advance the science of nitric oxide and innovate new nitric oxide product technology in every major market segment around the world.  This technology is disruptive and I’ve become a target of frivolous lawsuits from people trying to stop my innovations.  I know I’m doing the right thing when people come after me.  It means what I am doing is meaningful and transformational.  The most troubling aspect of all of this is that the lawsuits are from former partners and people I once trusted.  The truth is on my side so I will continue to fight against greed and envy.

How does low nitric oxide contribute to heart disease, Alzheimer’s, and other serious health issues, and how is Nitric Oxide Innovations working to solve these?


Nitric oxide is naturally produced in our bodies and is responsible for oxygenation of every cell in the body, but as we age, we produce less and less of it, and this loss contributes to the onset and progression of many diseases, such as ischemic heart disease, pulmonary hypertension, heart failure, stroke and Alzheimer’s disease. The science shows that there is really not a single disease where nitric oxide at the right dose at the right time would not be beneficial. Without it, blood vessels become stiff, constricted, inflamed, and as a consequence, organs, tissues and cells do not get sufficient oxygen and nutrients. Drugs or therapies that increase nitric oxide open the blood vessels, allowing for more efficient oxygen and nutrient delivery to every cell in the body. We have drug programs around these diseases and our topical nitric oxide drug for diabetic and pressure ulcer. Our lead nitric oxide drug for COVID-19, called Noviricid, is in phase 3 clinical trials, and we’re seeing patients improve on this drug therapy. We hope to have the FDA study completed by the end of 2022 and have several drugs approved over the next few years. 


Let’s turn to your popular skin care and beauty line, Pneuma Nitric Oxide. How does this “anti-aging” molecule work to restore youthful skin?


Without proper blood flow delivering oxygen and nutrients to the cells of the skin, the skin cells lose hydration, lose collagen, and lose their barrier function. As a result, the skin begins to sag, fine lines and wrinkles appear, and the skin becomes inflamed. Restoring blood flow by delivering topical nitric oxide can restore cellular function and turnover, improve collagen deposition, thereby improving the skin’s appearance, and restoring the color, tone, and texture almost immediately.  We have created a new product category in skin care. 

What do you enjoy most about your work, Dr. Bryan, or what drives you?

What keeps me going is the phone calls, emails, letters from people that tell me I’ve changed their lives. I spent 20 years in Academia where we made many discoveries, but my most satisfying position is entrepreneur and CEO of my companies and seeing products from my discoveries come to market and change lives. Most scientific discoveries never make it to commercial success, so being able to bring to market products that work and change lives is tremendously gratifying.We’ve accomplished a lot but we are just getting started.

Dr. Nathan S. Bryan

Founder & CEO of Nitric Oxide Innovations, LLC; Pneuma Nitric Oxide; & Bryan Nitriceuticals

Website:   |    |


Instagram: @drnathansbryan

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